Senior Scientist I/II, Bioinformatics (Ref 4223)

June 4, 2021


Following our recent exciting collaborations with both Merck KGaA, Darmstadt, Germany, and Novartis, and with an expanding small molecule drug discovery portfolio Artios Pharma is recruiting for an experienced Bioinformatician. This is an excellent opportunity to join a world class research team in a dynamic, small Biotech company based south of Cambridge, UK. Artios is focused on identifying and developing cancer treatments by exploiting novel targets within the DNA damage response (DDR), a scientific area of high expectation following the success of PARP inhibitors in the clinic. The company is actively working on an exciting portfolio of unique DNA repair projects.

We started our first clinical study with our small-molecule ATR inhibitor in February 2021.

Outline of the role
You will join the growing Bioinformatics team within Artios. In this role you will have the opportunity to use your bioinformatics skills to analyse clinical ‘omics datasets being generated by Artios and our collaborators to drive our biomarker-driven patient selection and stratification strategies. Your primary responsibilities will be to:

• Manage and perform high-quality analyses of ‘omics datasets generated from Artios translational studies and from patients recruited into Artios clinical trials.
• Work closely with the Bioinformatics Team Lead to develop and refine strategies for data management, analysis, integration and visualisation.
• Develop and implement bioinformatics analysis pipelines and data infrastructure as required. Identify, explore and implement technologies from open source platforms or vendors.
• Liaise with the Translational Science team and other Artios departments to help guide experimental design of ‘omics studies, and communicate key findings and results.
• Act as the key point of contact with CRO’s, sequencing vendors and software solution providers.
• Keep abreast of the latest developments in the oncology informatics space. Identify, test and implement novel methods/tools and datasets.

Qualifications and Experience

• Phd in bioinformatics/computational biology/genomics or other similar quantitative disciplines
• Minimum of 3 years post-PhD work experience
• Significant experience in oncology bioinformatics

• Experience in industry/ biotech and/or core facility environments
• Background in DNA Damage Response
• Experience of working with data from clinical samples e.g. FFPE tumour biopsies

Key Skills and Abilities

• Statistical programming, data manipulation, analysis, visualisation and reporting using R/Bioconductor, Shiny. Comfortable working in command-line environments.
• Significant experience of working with WES/WGS and RNA-Seq data
• Extensive experience in manipulation and interrogation of sequence data in FASTQ and BAM formats
• Extensive experience in sequencing data QC, alignment, variant calling and annotation, CNV analysis, calling fusions and structural variants using gold standard methods
• Database management experience
• Demonstrates initiative and willingness to learn
• Ability to work independently in an organised and methodical fashion
• Excellent communication and presentation skills
• Flexible approach to change

• Analysis of liquid biopsy sequencing data (ctDNA, CTCs)
• Experience of working with public cancer ‘omics datasets (TCGA, ICGC, PCAWG, GEO, DepMap)
• Multi-omic data integration and analyses
• Management of data in accordance with FAIR principles

This is a permanent position, offering an attractive salary & benefits package. Appointment will be at Senior Scientist I or II level depending on experience. If you have the right background, then please apply by sending your CV with a covering letter to quoting Ref 4223

The closing date is Monday 19 July 2021

In order to comply with UK Employment Law, all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.