Translational Science Lead – Senior or Principal Scientist (Ref 4238)

November 26, 2021


Translational Science Lead (Senior or Principal Scientist dependent upon experience)  Ref 4238

We have exciting collaborations with both Merck KGaA, Darmstadt, Germany, and Novartis, and with an expanding small molecule drug discovery portfolio, Artios Pharma is recruiting for a Translational Science Lead role. This is an excellent opportunity to join a world class research team in a dynamic, small Biotech company based south of Cambridge, UK.  Artios is focused on identifying and developing cancer treatments by exploiting novel targets within the DNA damage response (DDR), a scientific area of high expectation following the success of PARP inhibitors in the clinic.  The company is actively working on an exciting portfolio of unique DNA repair projects.

We have 2 clinical studies with our small molecules, ATR and Polθ inhibitors, in clinical development

Outline of the role

This role will join the growing Translational Science team who sit at the interface between research and development at Artios. Your primary responsibility will be to implement and manage pharmacodynamic and patient selection strategies in our clinical trials. You will work in a multi-disciplinary team across the scientific and clinical departments in Artios.  A large focus of the role will be working with contract research organisations to set up laboratories for clinical testing and deliver high quality validated assays.

 Qualifications and Experience

  • Educated to PhD level in a scientific discipline.
  • A strong background working in a translational oncology setting.
  • Experience of managing multiple external vendors and collaborators to deliver high value data to strict timelines in a clinical setting.
  • Experience in facilitating project team meetings, cross-functional communication, decision making  and budget management.
  • A background in DDR is desirable but not essential.

Job Responsibilities

  • Work closely with the Head of Translational Science to develop patient selection strategies and translate pharmacodynamic biomarkers from pre-clinical to clinical assays in a timely manner.
  • Identify technology and explore, where appropriate, novel platforms to enable delivery of clinical testing protocols.
  • Identify key CRO’s and manage the process of contracting them and actively track project progression up to, and including, the delivery of final project reports. Act as a key point of contact between Artios and the vendor.
  • Work with the Clinical Operations team to ensure all appropriate information on sample requirements and logistics is communicated to clinical trial sites and ensure that all documentation is in place prior to the start of a clinical trial.
  • Liaise with the biology team to ensure key reagents are available for assay development and any pilot work is performed.
  • Schedule regular project review meetings with relevant personnel internally and externally; organize core team meetings; including preparing meeting agendas, timely/appropriate review of action log as well as recording and circulation of meeting minutes.
  • Ensure all documentation is filed appropriately.

Key Skills and Abilities

  • Ability to work independently in an organised and methodical fashion.
  • High level of IT literacy.
  • Excellent communication and presentation skills.
  • Flexible approach to change.

This is a permanent position, offering an attractive salary & benefits package. It will be offered at Senior or Principal Scientist level, depending on experience. If you have the right background, then please apply by sending your CV with a covering letter to quoting

Ref 4238

The closing date Monday 31 January 2022 

In order to comply with UK Employment Law all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.

No agencies, thank you